Our Research / Nuestra investigación

Publications / publicaciones

        

         ... Working Progress!!

• Lobos-Parra, N., Lagos, F., Barra, R., Orrego, R. Induction of MT, HIF-1 and VEGF genes expressions as early metal-induced angiogenesis pathway biomarker in liver and gills of adult zebrafish (Danio rerio) exposed to Cd, Pb and As. Aquatic Toxicology (in prep).

• Guiñez, M., Valdés, J., Cerda, M., Castillo, A., Lobos, N., Valenzuela, G., Orrego, R. Spatiotemporal variability and environmental quality based on arsenic, copper, and cadmium determination through the longest river basin in the Atacama Desert, Northern Chile. Science of Total Environmentand: (in prep).

• Orrego, R., Romero-Murillo, P. Icaza, G., Barra, R. Mitogenome de novo assembly and annotation of Argopecten purpuratus reveals ATP8 gene presence: Insight in Structural and functional bioinformatics predictions. Mitochondrial DNA: (in prep).

• Orrego, R., Maya-Hun, G.., Romero-Murillo, P., Medina, D., García-Bartolomei, E., Valenzuela, F., Guiñez, R., Hengst, M. Phosphatidylinositol-5-Phosphate-4-Kinase-2-β (PI5P4K-2β) gene expression as an early  response to hyperosmotic stress in scallop Argopecten purpuratus. BMC Genomics (in prep).

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• Leiva, N., Montenegro, D., Orrego, R., Vidal, R., Gonzalez, MT. (2024). Tolerance of free-living larval stage of a parasite from coastal mining areas in northern Humboldt Current to copper pollution at low and high temperatures. PLOS ONE. DOI: 10.1371/journal.pone.0310473

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• Romero-Murillo, P., Campos, N., Orrego, R. (2023). Metal concentration in Isognomon alatus by stages and climatic seasons in San Andres Island, Colombian Caribbean. Acta Biologica Colombiana. DOI: 10.15446/abc.v28n3.97227

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• Muñoz, P., Rodríguez-Rojas, F., Celis-Pla, P, Lopez-Marras, A., Blanco-Murillo, B., Sola, I., Lavergne, C., Valenzuela, F., Orrego, R.,  Sanchez-Lizaso, J., Saez, C. (2023). Desalination effects on macroalgae (part a): laboratory-controlled experiments with Dictyota spp. from the Pacific Ocean and Mediterranean Sea. Frontiers in Marine Science. DOI: 10.3389/fmars.2023.1042782​

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• Muñoz, P., Rodríguez-Rojas, F., Celis-Pla, P, Lopez-Marras, A., Blanco-Murillo, B., Sola, I., Lavergne, C., Valenzuela, F., Orrego, R.,  Sanchez-Lizaso, J., Saez, C. (2023). Desalination effects on macroalgae (part b): transplantation experiments at brine- impacted sites with Dictyota spp. from the Pacific Ocean and Mediterranean Sea. Frontiers in Marine Science. DOI: 10.3389/fmars.2023.1042782

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• Garcia-Bartolomei, E.,  Vasquez, V., Rebolledo, G.,  Vivallo, A., Acuña, T., Rebolledo, R., Orrego, R., Barra., R. (2022). Defining priority areas for the sustainable development of the desalination industry in Chile: a GIS multi-criteria analysis approach. Sustainability MDPI. DOI: 10.3390.//su14137772

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• Orrego, R.; Guchardi, J.; Barra, R; Hewitt, M; Holdway, H. (2021). Sex-related embryotoxicity of pulp mill effluent extracts in medaka (Oryzias latipes) female leukophore-free FLFII strain. Environmental Toxicology and Chemistry: DOI: 10.1002/etc.5115

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• Quiroz-Jara, M.,  Casini, S., Fossi, C., Orrego, R., Gavilán, J.F., Barra, R. (2021). Integrated Physiological Biomarkers Responses in Wild Fish Exposed to Anthropogenic Gradient in the Biobío River, Central Chile. Environmental Management. DOI: 10.1007/s00267-021-01465-y

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• Barra, R., Chiang, G., Saavedra, M., Orrego, R., Servos, M., Hewitt, M., McMaster, M., Bahamonde, P., Tucca, F., Munkittrick, K. (2021). Endocrine Disruptor Impacts on Fish From Chile: The Influence of Wastewaters. Frontier in Endocrinology 12: 611281. DOI: 10.3389/fendo.2021.611281

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• Garcia-Cegarra, A., Luc-Jung, J., Orrego, R., Padilha, J., Malm, O., Ferreira-Braz, B. Santelli, R., Pozo, K., Pribylova, P., Alvarado, M., Azat, C., Kidd, K., Espejo, W., Chiang, G. Bahamonde, P. (2021). Bioaccumulation and maternal transfer of pollutants in long-finned pilot whales stranded in Chilean Patagonia. Science of Total Environmentand 770. 145259. DOI: 10.1016/j.scitotenv.2021.145259

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• Garcia-Cegarra, A., Ramirez, R., Orrego, R. (2020). Red-legged cormorant uses plastic as nest material in an artificial breeding colony of Atacama Desert Coast. Marine Pollution Bulletin 160. 111632. DOI: 10.1016/j.marpolbul.2020.111632

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• Rodriguez-Rojas, F., Lopez-Marras, A., Celis-Pla, P., Muños, P., Garcia-Bartolomei, E., Valenzuela, F., Orrego, R., Carratala, A., Sanchez-Lizaso, JL., Saez, C. (2020). Ecophysiological and cellular stress responses in the cosmopolitan brown macroalga Ectocarpus as biomonitoring tools for assessing desalination brine impacts. Desalination 489: 114527. DOI: 10.1016/j.desal.2020.114527 

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• Orrego, R., Hewitt, L.M., McMaster, M., Chiang, G., Quiroz, M., Munkittrick, K., Gavilán, J.F., Barra, R. (2019). Assessing wild fish exposure to ligands for sex steroid receptors from pulp and paper mill effluents in the Biobio River Basin, Central Chile.  Ecotoxicology and Environmental Safety. 171: 256-263. DOI: 10.1016/j.ecoenv.2018.12.092

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• Tapia, J., Dorador, C., Orrego, R., Valdes, J., Harrod, C. (2018). Geologic and anthropogenic sources of contamination in settled dust of a historic mining port city in northern Chile: Health risk implications. PeerJ DOI: 10.7717/peerj.4699

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• Romero-Murillo, P., Orrego, R. ; Espejo, W.; Barra, R.; (2018). Embryo-larvae and juvenile toxicity of Pb and Cd in Northern scallop Argopecten purpuratus. Environmental Monitoring and Assessment,  190(16):1-13. DOI: 10.1007/s10661-017-6373-9

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• Orrego, R.; Milestone, C.; Hewitt, M.; Guchardi, J.; Heid-Furley, T.; Slade, A.; MacLatchy, D.; Holdway, D. (2017). Evaluating the Potential of Effluent Extracts from Pulp and Paper Mills in Canada, Brazil and New Zealand to Affect Fish Reproduction: Estrogenic Effects in Fish. Environmental Toxicology and Chemistry, 46: 1547-1555. DOI: 10.1002/etc.3675

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• Miandare, K.H.; Yarahmadi, P.; Aramoon, A., Mohammadi, M.; Jalali, A., Orrego, R.  (2017). Exposure of rainbow trout to industrial wastewater is associated with immune-related gene expression and haematological changes. International Journal of Environmental Science and Technology, 14: 623-630. DOI: 10.1007/s13762-016-1185-y

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• Milestone, C.B., Orrego, R., Scott, P.D.; Waye, A.; Kohli, J.; O'Connor, B.I.; Smith, B.; Engelhardt, H.; Servos, M.R.; Maclatchy, D.L.; Smith, D.S.; Trudeau, V.L.; Arnason, J.T.; Kovacs, T.; Heid Furley, T.; Slade, A.H.; Holdway, D.A.; Hewitt, L.M. (2012). Evaluating the potential of effluents and wood feedstocks from pulp and paper mills in Brazil, Canada, and New Zealand to affect fish reproduction: chemical profiling and in vitro assessments. Environmental Science and  Technology, 46 (3): 1849-58. DOI: 10.1021/es203382c

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• Beyger, L.; Orrego, R.; Guchardi, J.; Holdway, D. (2012). The acute and chronic effects of endosulfan pulse-exposure on Jordanella floridae (Florida flagfish) over one complete life-cycle. Ecotoxicology and  Environmental Safety, 76 (2): 71-8. DOI: 10.1016/j.ecoenv.2011.09.015 

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• Orrego, R.; Pandelides, Z.; Guchardi, J.; Holdway, D. (2011). Effects of pulp and paper mill effluent extracts on liver anaerobic and aerobic metabolic enzymes in rainbow trout. Ecotoxicology and Environmental Safety, 74 (4): 761-8. DOI: 10.1016/j.ecoenv.2010.10.042 

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• Orrego, R.; Guchardi, J.; Beyger, L.; Krause, R.; Holdway, D. (2011). Comparative embryotoxicity of pulp mill extracts in rainbow trout (Oncorhynchus mykiss), American flagfish (Jordanella floridae) and Japanese medaka (Oryzias latipes). Aquatic Toxicology, 104 (3-4): 299-307. DOI: 10.1016/j.aquatox.2011.04.015 

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• Orrego, R.; McMaster, M.; Van Der Kraak, G.; Holdway, D. (2010). Effects of pulp and paper mill effluent extractives on aromatase CYP19a gene expression and sex steroid levels in juvenile triploid rainbow trout. Aquatic Toxicology, 97 (4): 353-60. DOI: 10.1016/j.aquatox.2010.01.002

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• Orrego, R.; Guchardi, J.; Krause, R.; Holdway, D. (2010). Estrogenic and anti-estrogenic effects of wood extractives present in pulp and paper mill effluents on rainbow trout. Aquatic Toxicology, 99 (2): 160-7. DOI: 10.1016/j.aquatox.2010.04.016

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• Chiang, G.; Munkittrick, K.; Orrego, R.; Barra, R. (2010). Monitoring of the Environmental Effects of Pulp Mill Discharges in Chilean Rivers: Lessons Learned and Challenges. Water Quality Reseach Journal of Canada, 45 (2): 111-22.

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• Orrego, R.; Guchardi, J.; Hernandez, V.; Krause, R.; Roti, L.; Armour, J.; Ganeshakumar, M.; Holdway, D. (2009). Pulp and paper mill effluent treatments have differential endocrine-disrupting effects on rainbow trout. Environmental Toxicology and Chemistry, 28 (1): 181-9. DOI: 10.1897/08-191.1 

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• Orrego, R.; Marshall Adams, S.; Barra, R.; Chiang, G.; Gavilan, J.F. (2009). Patterns of fish community composition along a river affected by agricultural and urban disturbance in south-central Chile. Hydrobiologia, 620 (1): 35-46. DOI: 10.1007/s10750-008-9613-8

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• Jonsson, M.E.; Orrego, R.; Woodin, B.R.; Goldstone, J.V.; Stegeman, J.J. (2007). Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicoogy andl Applied Pharmacology, 221 (1): 29-41. DOI: 10.1016/j.taap.2007.02.017

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• Orrego, R.; Burgos, A.; Moraga-Cid, G.; Inzunza, B.; Gonzalez, M.; Valenzuela, A.; Barra, R.; Gavilan, J.F. (2006). Effects of pulp and paper mill discharges on caged rainbow trout (Oncorhynchus mykiss): Biomarker responses along a pollution gradient in the Biobio River, Chile. Environmental Toxicology and Chemistry, 25 (9): 2280-87. DOI: 10.1897/05-385R.1

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• Inzunza, B.; Orrego, R.; Penalosa, M.; Gavilan, J.F.; Barra, R. (2006). Analysis of CYP4501A1, PAHs metabolites in bile, and genotoxic damage in Oncorhynchus mykiss exposed to Biobio River sediments, Central Chile. Ecotoxicology and Environmental Safety, 65 (2): 242-51. DOI: 10.1016/j.ecoenv.2005.07.019

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• Orrego, R.; Moraga-Cid, G.; Gonzalez, M.; Barra, R.; Valenzuela, A.; Burgos, A.; Gavilan, J.F. (2005). Reproductive, physiological, and biochemical responses in juvenile female rainbow trout (Oncorhynchus mykiss) exposed to sediment from pulp and paper mill industrial discharge areas. Environmental Toxicology and Chemistry, 24 (8): 1935-43. DOI: 10.1897/04-251r1.1

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• Orrego, R.; Jimenez, B.; Bordajandi, L. R.; Gavilan, J. F.; Inzunza, B.; Abad, E.; Gonzalez, M. J.; Rivera, J.; Barra, R. (2005). EROD induction and PCDD/F levels in fish liver from the Biobio River in Chile. Chemosphere, 60 (7): 829-35. DOI: 10.1016/j.chemosphere.2005.02.008

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• Fuentes-Rios, D.; Orrego, R.; Rudolph, A.; Mendoza, G.; Gavilan, J. F.; Barra, R. (2005). EROD activity and biliary fluorescence in Schroederichthys chilensis (Guichenot 1848): biomarkers of PAH exposure in coastal environments of the South Pacific Ocean. Chemosphere, 61 (2): 192-9. DOI: 10.1016/j.chemosphere.2005.02.062

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• Barra, R.; Sanchez-Hernandez, J.; Orrego, R.; Parra, O.; Gavilan, J.F. (2001). Bioavailability of PAHs in the Biobio river  Chile): MFO activity and biliary fluorescence in juvenile Oncorhynchus mykiss. Chemosphere, 45: 439-445. DOI: 10.1016/s0045-6535(01)00041-8